Molecular Detection of Human Cytomegalovirus in Iraqi Patients with Breast Cancer

A total number of 70 formalin-fixed paraffin embedded tissue blocks obtained from Iraqi patients with histopathologically diagnosed breast cancers, as well as 20 apparently healthy breast tissues (as a control group), were related to the period from January 2009 to August 2012, have been enrolled for CMV-DNA detection by in situ hybridization (ISH) technique. The mean age of patients was 41.7 years. CMV was demonstrated by ISH in (34.3%) breast cancer tissues (24 out of 70) which statistically show highly significant difference (p <0.001) when compared to the control breast tissues group (all were negative by ISH for CMV-DNA). Histopathological diagnosis has shown invasive ductal breast carcinomas in (54.3%) of cases , followed by the medullary breast carcinomas (28.6%) , then lobular breast carcinomas (17.1%) while the grading system revealed well grade breast carcinoma in 68.6% of cases followed by poorly grade (20%) and moderate grade (11.4%).